COLIN PAUL
SPEARS,
MD
CEO and Founder, Fibonacci Phyllotaxis Inc. (dba Fibons)
Professor Emeritus, California Northstate
University College of Medicine
Personal Information
Work Address |
FPI dba Fibons 3415
American River Dr., Ste. C Sacramento
CA 95864-5741 |
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Telephone |
(916)
502-0816 cell/text (916)
692-8480 office |
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Fax |
(916)
482-4710 |
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Email |
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Citizenship |
USA |
Education
College |
Queens College, City University of
New York,
Queens,
N.Y.,
B.A., Chemistry-Biology 1966,
cum laude |
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Medical
School |
Downstate Campus, State University of New
York, Brooklyn,
N.Y.,
M.D., 1970, cum laude |
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Internship |
U.S. Public Health Service Hospital,
San Francisco, California, 1970-1971,
Straight Medicine |
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Associateship |
U.S. Public Health Service Hospital,
San Francisco, California, 1971-1973,
National Aeronautics and Space Administration (NASA)
Research Associate in Cardiology |
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Residency |
LAC/USC-MC,
Los Angeles, California, 1973-1974,
Internal Medicine |
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Fellowships |
LAC/USC-MC,
Los Angeles, California,
1974-1977, Medical Oncology USC
Comprehensive Cancer
Center, Los Angeles,
California,
1977-1983, Research Scholar (Advisor: Prof.
Charles Heidelberger) Hematology,
The Hospital
of the Good Samaritan,
Los Angeles, 1983-1984 |
Honors and Distinction
National
Cancer Institute, NIH |
Cancer
Research Training Grant Award,
1974 |
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National
Cancer Institute, NIH |
Cancer
Clinical Training Grant
Award, 1975 |
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Meetings Best Abstracts |
American Association for
Cancer Research, 1979;
American Society of
Clinical Oncology, 1986
and 1989 Co-author,
1st Place Award,
The Genetic Revolution,
San Diego, 1994 |
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Member |
International Who’s Who of Professionals Distinguished
Leadership Award, International Directory of Distinguished Leadership,
1998 |
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Teaching Awards |
Consultant of the Year, Family Practice Residency Program,
Mercy General Hospital,
Sacramento, CA, 2003, 2008
and 2009 |
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Invited Lectures |
Management of Breast Cancer
in the U.S.,
Department of Surgery, Sahlgrenska University
Göteborg,
Sweden, 1992 Discussant, Clinical Pharmacology
Section, American Society of Clinical
Oncology, 1993 Keynote Speaker, Nordic Clinical Pharmacology Group,
Göteborg,
Sweden, 1995 Moderator
and Speaker: Trimetrexate/5-FU: Review of Preclinical
Rationale and Pharmacodynamics, U.S.
BioScience Symposium,
St. Petersberg, Fl.,
8/1998 |
Achievements
Cancer Drug Development |
Pharmacodynamic studies
of thymidylate synthase (TS)
inhibition in vivo 1979 and in clinical
tumor biopsies, 1982 using fluorouracil, firsts for
any cancer drug Invention of CoFactor, for
improvement of 5-FU therapy, USC, 1982, Patents in 1990s, PI role in
Phase IIB trial including at Sierra Hematology & Oncology and Mercy
General Hospital in 2003, leading to phase III trials (currently under Isofol with Merck) First Investigator
for national trial
of breast cancer treatment vaccine, 1994,
USC-Norris Cancer Center Addition of folate to Alimta (pemetrexed), a TS inhibitor, with successful Registration Trial in NSCLC, Eli Lilly 1999 |
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Chemistry |
Methods for Swain-Scott-Spears Nucleophilic
Selectivity of aliphatic alkylating agents using green protic
chemistry and physiological conditions (1980-present) Invention of selenium and selenone alkylating agents using physical
organic chemical kinetics, 1990’s Demonstration in 2018 that bendamustine is a classical alkylating agent, leading to FDA
relabeling Studies of evofosfamide
kinetics under hypoxic conditions, explaining its failure in the
clinic Studies of ethylphenyglycidate
(Strawberry Aldehyde 2) showing potential mutagenicity risk |
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Mathematics |
Generalized Fibonacci Number,
Definition of,
cited in MathWorld.com (Mathematica; and the Encyclopedia of
Mathematics,
CRC Publishing, 2003-present) Mathematics of
volume doubling relationships,
1979, 1984, and the 1-2-3-4 of
Volume and Area Doubling Rulers, 2021 Erdős Number
3 Fibonacci biology, sequential slide video-microscopy (SSVM) for phyllotaxic patterns in Cotula
sericea, 2017 |
Licensure
California Physician and Surgeon License G23022 since 1970
DEA
AS5295301
NPI
1023084720
ORCiD ID: 0003-003-2822-3620
Web
of Science Researcher ID HNS-4212-2023
Board Certification
ABIM Member Number 52779
Medicine, American Board of Internal Medicine, 1982 (Lifetime Certification)
Medical
Oncology, ABIM, 1985 (Lifetime Certification)
Professional
Appointment
· Research Scholar: University of
Southern Cancer
Center, Los Angeles,
1977 – 1982 · Assist Prof
of Res Med:
USC School of Medicine,
1982 – 1983 · Clin Assist
Prof of
Med:
USC School of Medicine,
1985 – 1986 · Assoc Prof
Medicine: Medical Oncology, USC
School of Medicine,
1986 – 1997 · Prof Clin Medicine: Medical Oncology,
USC School of Medicine,
1997 – 1999 ·
Active Staff, Medical Oncology &
Hematology,
Huntington Memorial
Hospital, Pasadena, California, 1997 – 1999 · Member,
Huntington Medical Research Institute, Pasadena,
California, 1996
-1999 · Research Scholar, USC Department
of Chemistry, Los Angeles, CA,
1998 – 2001 ·
Senior
Clinical Research Physician,
Oncology
Products, Eli Lilly & Company,
Lilly Corporate Center, Indianapolis,
Indiana. 01/04/1999 -
08/04/1999 ·
Attending Physician, Woodland Clinic, Woodland, CA,
03/2001 - 12/2001 ·
Attending Physician, Sacramento Center of Hematology
&Medical Oncology, 2800 L
Street, Sutter Cancer Center, Sacramento, CA. 12/1999 – 03/2001 ·
Attending
Physician, Sierra
Hematology & Oncology, Suite 360,
3939 J Street, Sacramento, CA 95819, 03/26/2001 – present · Partner, Sierra Hematology & Oncology Medical
Centers, 2001 – 2017
Retirement · Chairman, Cancer Committee, Mercy General Hospital,
Community Comprehensive Cancer Center, Sacramento, 2008 – 2016 · Chairman, Weekly Tumor
Conference, Mercy General
Hospital, Sacramento, 2008 – 2014 ·
Member, Institutional
Review Board, Catholic HealthCare West,
Sacramento Region 2001
– 2017 ·
Clinical Professor, California Northstate
University, College of Medicine 2013 - 2020 |
Graduate & Post-Graduate Teaching
Graduate &
Post-Graduate Teaching USC, 1985-1997 1. Sang-Ihn Kang, Ph.D., 1985-9. Synthetic chemist. Won a National
Academy of Sciences National Research Council Fellowship to work with Dr.
Kurt Kohn at the National Cancer Institute’s Laboratory of Molecular
Pharmacology. 2. Jashovam Shani, Ph.D., 1984-5. UICC Eleanor Roosevelt
Fellow. Appointed Director of the Food and Drug
Administration of Israel in 1989. 3. Nitya G.
Kundu, Ph.D., Summer, 1988. UICC Traveling Fellowship, from his post as
Professor of Chemistry,
Indian Association for the Cultivation of Science, Calcutta, India. 4. Andrea H.
Hayes, Summer, 1987. Junior, pre-med student. USC research done before entry
into Dartmouth
Medical School. 5. Shawn
Granger, Summer 1988. West Point graduate, USC School of Medicine. 6. Ph.D.
Guidance Committee, Dean of Graduate Studies Representative, Paresh Sanghani, 1996; Elaine Chen, 1992
(USC School of Pharmacy);Jingwen
(Jenny) Zheng, 1994; Jeff Wang, 1994. 7. Helena
Gustavsson, premedical student, U. of Göteborg,
Sweden, 1992-93. 8. Francisco Bravo
H.S. preceptor and Science Fair judge, 1991 -1999. 9. University
of Göteborg M.D./Ph.D. graduate USC studies
preceptor for: Magnus Berne, M.D., Ph.D. (1986),
Roland Frösing, M.D., Ph.D. (1992), Per-Anders
Larsson (1994). CNUCOM, 2014-2019 1. Aye Khine, 2nd-Yr. Doctoral Candidate, Prolonged
Myelosuppression of Bendamustine, and its Low
Nucleophilic Selectivity. 2. Sylvia
Bowditch, Cristopher Phillips, and Jacob Stoker, 2nd-Yr. Doctoral Candidates Barriers to
Access to
Care at Chemotherapy Infusion Centers, by Patients with Paraplegia. |
Military
Service
U.S.
Public Health Service, Lt
(03),
1970-1973
Presidio, Marine Hospital, San Francisco, California
Society Memberships
Memberships
Past and Present ·
American
Medical Association ·
Sacramento-El
Dorado County Medical Association ·
Sierra
Sacramento Valley Medical Society ·
Los
Angeles County Medical Association ·
Pasadena
Medical Society ·
California
Medical Association ·
American
Association for Cancer Research ·
American
Society for Clinical Oncology ·
Association
of Northern California Oncologists ·
American
Society of Hematology ·
American
Chemical Society ·
American
Society for Cell Biology - ASCB ·
SPIE-The
International Society for Optical Engineering ·
International
Union of Pure and Applied Chemistry ·
International
Society for the Study of Xenobiotics ·
International
Society for the Study of Comparative Oncology ·
Mathematics
Association of America ·
American
Mathematics Society ·
Fibonacci
Association ·
American
Statistical Association ·
South
Bay Writers Club (California Writers Club) |
Consultantships
Biokeys Corporation: Consultant, Los Angeles, CA, 1997-1999
US Bioscience: Investigator Meetings Faculty, 1997-1999
Rhône-Poulenc-Rorer: Speaker, Area Advisory Board,
1997-1999
NCI: Program Project
Reviewer, Division of Cancer
Treatment, 1988
(Memorial
SKCC), 1991 (Roswell
Park),
1993 (Univ.
of Michigan), 1994 (Yale Univ.)
NCI, NIH: Phase I-II Cancer
Pharmacokinetics Contracts Review
Committee,
1997
NIH, PHS SBIR and STTR: Reviewer, 1994,
1995
NCI: Extramural
R13
Reviewer, 1991
NCI: Special Emphasis Panel,
Chemopreventive Agent Contracts,
1992
NATO: Referee, Collaborative Research Grants, 1991
SPIE: International
Working Group in Electronic Imaging
Regional Cancer Treatment: Member, Editorial Board
Reviewer: J. Med. Chem., Cancer Res.,
Cancer, J. Biol. Chem.,
J. Natl. Cancer Inst.,
Biochem. Pharmacol., Eur. J.
Oncol.,
Cancer Chemother. Pharmacol.,
Fibonacci Quarterly, Oncology Research,
Gastroenterology, Int. J.
Cancer, Drugs, J. Spinal Cord Med.
Hospital Staff Privileges
CURRENT
Mercy General Hospital, Sacramento, CA
PRIOR
Sacramento, CA: Sutter General Hospital
and Sutter Memorial
Hospital.
Davis, CA: Sutter Davis Hospital, 1999-2001.
Pasadena, CA: Huntington Memorial Hospital and St. Luke Medical Center, 2/97 -
1/99.
Los
Angeles, CA:
The Hospital
of the Good Samaritan, 1984-7, Norris Cancer
Hospital, 1987-1997,
USC University Hospital, 1992-1997.
Locum Tenens
Practice of Mark Farbstein,
Hematology/Medical Oncology,
Pasadena, CA, 11/96
Practice of Lowell Irwin,
M.D. and M. Mercedes Brenneisen, M.D.,
MedicalOncology/Hematology, Los Angeles and San Gabriel
Valley,
CA, 1990s.